Paul S Mischel Selected Research

Growth Factor Receptors

12/2019	mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma.
1/2019	Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling.
10/2018	mTOR Complexes as a Nutrient Sensor for Driving Cancer Progression.
11/2016	An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.
1/2016	mTORC2 activity in brain cancer: Extracellular nutrients are required to maintain oncogenic signaling.
7/2015	Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance.

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Paul S Mischel Research Topics

Disease

123	Neoplasms (Cancer) 05/2022 - 09/2002
88	Glioblastoma (Glioblastoma Multiforme) 11/2021 - 09/2002
30	Brain Neoplasms (Brain Tumor) 11/2021 - 10/2004
29	Glioma (Gliomas) 01/2020 - 09/2002
4	Carcinogenesis 12/2021 - 06/2009
4	Melanoma (Melanoma, Malignant) 04/2013 - 04/2010
3	Hypoxia (Hypoxemia) 01/2016 - 05/2007
3	Leukemia 01/2015 - 03/2013
3	Edema (Dropsy) 01/2012 - 05/2007
2	Uveal melanoma 09/2021 - 01/2021
2	Neoplasm Metastasis (Metastasis) 09/2021 - 01/2015
2	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2019
2	Disease Progression 10/2015 - 01/2011
2	Lung Neoplasms (Lung Cancer) 01/2013 - 05/2012
2	Medulloblastoma 01/2012 - 01/2008
1	Oropharyngeal Neoplasms 12/2021
1	Colorectal Neoplasms (Colorectal Cancer) 12/2021
1	Rupture 01/2021
1	Chromosomal Instability (Chromosome Stability) 01/2021
1	Ovarian Neoplasms (Ovarian Cancer) 01/2020

Drug/Important Bio-Agent (IBA)

21	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 10/2004
21	Phosphotransferases (Kinase)IBA 01/2016 - 06/2003
20	ErbB Receptors (EGF Receptor)IBA 01/2018 - 09/2002
17	Proteins (Proteins, Gene)FDA Link 05/2022 - 04/2005
17	epidermal growth factor receptor VIIIIBA 01/2017 - 09/2002
15	Mechanistic Target of Rapamycin Complex 2IBA 01/2020 - 11/2011
14	Pharmaceutical PreparationsIBA 11/2021 - 02/2004
10	EnzymesIBA 05/2022 - 08/2009
10	TOR Serine-Threonine KinasesIBA 01/2020 - 08/2006
8	Sirolimus (Rapamycin)FDA Link 02/2019 - 08/2006
8	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 09/2011
7	Mechanistic Target of Rapamycin Complex 1IBA 01/2020 - 08/2009
7	Phosphoric Monoester Hydrolases (Phosphatases)IBA 08/2012 - 01/2007
6	LipidsIBA 05/2022 - 08/2010
6	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2019 - 07/2005
6	Growth Factor ReceptorsIBA 12/2019 - 07/2015
6	Biological ProductsIBA 01/2016 - 04/2003
6	Bevacizumab (Avastin)FDA Link 01/2012 - 07/2009
5	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 02/2019 - 12/2011
5	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 02/2019 - 01/2013
5	Tyrosine Kinase InhibitorsIBA 01/2015 - 01/2007
5	TensinsIBA 08/2012 - 01/2007
4	CholesterolIBA 11/2016 - 08/2009
4	MTOR InhibitorsIBA 10/2015 - 08/2009
4	LigandsIBA 01/2015 - 09/2002
4	Adenosine Triphosphate (ATP)IBA 10/2013 - 09/2011
4	Erlotinib Hydrochloride (CP 358,774)FDA Link 05/2012 - 11/2005
3	Temozolomide (Temodar)FDA LinkGeneric 11/2021 - 01/2011
3	Histones (Histone)IBA 01/2020 - 01/2016
3	Messenger RNA (mRNA)IBA 01/2018 - 07/2005
3	Biomarkers (Surrogate Marker)IBA 01/2016 - 04/2009
3	Transcription Factors (Transcription Factor)IBA 10/2015 - 06/2008
3	src-Family KinasesIBA 05/2014 - 04/2009
3	Fatty Acids (Saturated Fatty Acids)IBA 05/2013 - 08/2009
3	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 01/2013 - 01/2007
3	Small Interfering RNA (siRNA)IBA 01/2012 - 01/2008
3	VemurafenibIBA 05/2011 - 04/2010
3	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 07/2009 - 11/2005
2	NucleotidesIBA 05/2022 - 01/2019
2	Lysine (L-Lysine)FDA Link 04/2021 - 01/2020
2	ChromatinIBA 01/2021 - 11/2019
2	Oxidoreductases (Dehydrogenase)IBA 12/2019 - 12/2009
2	Ligases (Synthetase)IBA 01/2019 - 11/2009
2	Amino Acids FDA Link 10/2018 - 07/2017
2	IntegrinsIBA 12/2017 - 05/2014
2	Interleukin-6 (Interleukin 6)IBA 01/2017 - 04/2013
2	Liver X ReceptorsIBA 11/2016 - 10/2011
2	MethyltransferasesIBA 01/2016 - 03/2013
2	Lactic Acid (Lactate)FDA LinkGeneric 01/2016 - 09/2011
2	hydrogen sulfite (bisulfite)IBA 11/2014 - 10/2012
2	MicroRNAs (MicroRNA)IBA 11/2014 - 08/2012
2	Focal Adhesion Protein-Tyrosine KinasesIBA 05/2014 - 04/2009
2	Tyrosine (L-Tyrosine)FDA Link 08/2012 - 06/2009
2	Everolimus FDA Link 06/2012 - 03/2009
2	Angiogenesis InhibitorsIBA 01/2012 - 01/2010
2	Protein Kinases (Protein Kinase)IBA 11/2011 - 04/2010
2	Sterol Regulatory Element Binding Protein 1IBA 10/2011 - 12/2009
2	Lapatinib (GW572016)FDA Link 10/2011 - 12/2009
2	Phosphatidylinositols (Phosphatidylinositol)IBA 10/2011 - 06/2003
2	Deoxyglucose (2 Deoxy D glucose)IBA 09/2011 - 08/2009
2	Protein Isoforms (Isoforms)IBA 09/2011 - 01/2011
2	Irinotecan (Camptosar)FDA LinkGeneric 01/2010 - 02/2004
2	Dasatinib (BMS 354825)FDA Link 09/2009 - 04/2009
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2008 - 05/2007
2	OligonucleotidesIBA 09/2004 - 07/2003
2	Matrix Metalloproteinases (MMPs)IBA 01/2004 - 09/2002
1	Circular DNAIBA 12/2021
1	Oncogene Proteins (Oncogene Protein)IBA 11/2021
1	Fluoxetine (Prozac)FDA LinkGeneric 11/2021
1	Polycomb Repressive Complex 1IBA 01/2021
1	olaparibIBA 01/2020
1	rucaparibIBA 01/2020
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2020
1	Histone Deacetylases (Histone Deacetylase)IBA 12/2019
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 12/2019
1	Pyruvic Acid (Pyruvate)IBA 12/2019

Therapy/Procedure

52	Therapeutics 12/2021 - 09/2002
5	Drug Therapy (Chemotherapy) 01/2019 - 02/2004
4	Radiotherapy 05/2014 - 07/2006
2	Molecular Targeted Therapy 01/2010 - 07/2009